Thrombin-antithrombin complex

Converse to UFH, LMWH action is primarily directed against factor Xa, because most of the chains are not sufficiently long to form the ternary complex necessary for the inactivation of thrombin (<50% of the chains contain at least the 18 saccharide units needed for the formation of the ternary heparin-thrombin-antithrombin complex) (Fig. IC). Depending on the LMWH, the antithrombin-anti-Xa activity ratio varies from 1.9 (tinzaparin) to 3.8 (enoxaparin) (2). 

There are several lines of evidence demonshahng that CSA causes endothelial cell injury. CSA has a direct cytotoxic effect on cultured endothelial cells and inhibits human umbilical endothelial cell proliferahon [74,75]. CSA increases the plasma level of endothelial damage markers, such as Von Willebrand factor, endothelin tissue factor pathway inhibitor, P-selectin and thrombin-antithrombin complexes in renal and heart transplant patients [76-79]. Similarly, the release of Von... 

B4. Bauer, K. A., Teitel, J. M., and Rosenberg, R D., Assays for the quantitation < antitfarombin 111 thrombin-antithrombin complex and prothrombin activation fragments. In Disorders of Thrombin Formation (R W. Colman, ed.), pp. 142-155. Churchill-Ljvingstone, Edinburgh and London, 1983. 

Compared to placebo patients, patients who received rhAT showed significant inhibition of the generation of two markers of thrombin activation - prothrombin fragment 1.2 and thrombin-antithrombin complex. 

The adsorption of the thrombin-antithrombin complex (T-AT) on various anionic anticoagulant polystyrene derivatives results in a quenching of the T-AT fluorescence. 

Thrombin-antithrombin complex (TAT) concentrations were measured using a specific radioimmunoassay . 

Fig. 5. Thrombin-antithrombin complex generation in plasma PSSO2GIU O - PSSO3 A. ...

H.K. Lau and R.D< Rosenberg, The inactivation and characterization of a specific antibody population directed against the thrombin-antithrombin complex, J. Biol. Chem. 255 5885 (1980). 

C. Fougnot, M. Jozefowicz and R.D. Rosenberg, Catalysis of the generation of thrombin-antithrombin complex by insoluble anticoagulant polystyrene derivatives. Biomat., submitted. 

Thrombin-antithrombin complexes (TAT) stress markers, it is clear that OP intoxication represents a stress situation. In this context, an increase in Alanine aminotransferase (ALT) can also be considered as a stress marker and not indicative of liver damage. 

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