Thiosemicarbazones with starch dialdehyde

Thiosemicarbazones and Other Condensation Products with Starch Dialdehyde. 292... 

Starch dialdehyde condenses readily with amino amides2624 and diamines,2625 and forms oximes with hydroxylamine.2626 The reaction of starch dialdehyde with isoniazid, 4 -formacelanilide thiosemicarbazone, 4 - amin o b e n z a I de h y de thiosemicarbazone or thiosemicarbazone, produced the corresponding condensation products.613-615 617 2627-2629 Hydrazones were readily formed when hydrazine and its derivatives were blended with starch dialdehyde and acidified with acetic acid2543,2630 or simply on heating the reaction mixture.2631 Condensation of starch... 

Thiosemicarbazones of starch dialdehyde and thiosemicarbazones and condensation products of starch dialdehyde with isoniazid were evaluated for their antituberculostatic activity, and showed positive effects with mice that were intravenously infected with Mycobacterium tuberculosis. 613-614-617-2627-2629 These results were contradicted by other authors615,616 who showed acceleration of M. tuberculosis growth in vitro in contact with starch dialdehyde thiosemicar-bazone. A potential application of this compound was suggested in tuberculosis taxonomy. 

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