Thiopropazate

Chemical Name 4-[3-(2-Chlorophenothiazin-10-yl)propyl] -1-piperazine-ethanol acetate Common Name — 

A mixture of 155 parts of 2-chloro-10-(7-chloropropyl)phenothiazine, 75 parts of sodium 

A mixture of 50 parts of the distillate, 25.6 parts of 3-bromoethyl acetate, 10.7 parts of potassium carbonate and 400 parts of toluene is stirred at reflux temperature for 16 hours. The mixture is heated with water. The organic layer is separated, washed with water and extracted with dilute hydrochloric acid. The resulting extract is washed with benzene, rendered alkaline and extracted with benzene. The resulting benzene solution is dried over anhydrous potassium carbonate, filtered and concentrated. The residue is dissolved in 300 parts of ethanol and treated with 2.2 equivalents of a 25% solution of anhydrous hydrochloric acid in 2-pro-pa nol. The resulting crystals are recrystallized from 400 parts of ethanol and 10 parts of water. The dihydrochloride of N-( 3-acetoxyethyl)-N -[7-(2 -chloro-10 -phenothiazine)propyl] piperazine melts unsharply at about 200°C to 230°C. 

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Bromo-2. (3"-dimethylaminopropyD-amino-4 -chlorodiphenyl sulfide Chlorproethazine HCI 2-Bromoethanol Perphenazine /3-Bromoethyl acetate Thiopropazate... 

C2H3CIO 75-36-5) see Acebutolol Acetiamine Acetylcholine chloride L-Alanine Benfurodil hemisuccinate . Chlorprothixene Flumetasone Ibuprofen lotalamic acid loxitalamic acid Levodopa Methestrol dipropionate Midecamycin acetate Naproxen Nimesulide Paclitaxel Paramethasone Phensuximide Retinol Rocuronium bromide Rofecoxib Ropinirole Tazarotene Thiopropazate Tiracizine Vecuronium bromide... 

Thiazinone, synthesis, 280 Thiazosulfone, 141 Thiethylperazine, 382 Thiobarbital, 275 Thiofuradene, 231 Thiopental, 274 Thiopropazate, 383 Thioridazine, 389 Thiothixene, 400 Thonzylamine, 52 Thrombosis, 397 Thyroid gland, 95 Thyroxine, 95, 97 Tolazamide, 137 Tolazoline, 241 Tolbutamide, 136 Tolycaine, 17... 

Chlorpromazine, diethazine, ethopropa-zine, mequitazine, methdilazine, pera-zine, phenothiazine, prochlorperazine, thiopropazate, trimeprazine... 

Acepromazine, carphenazine, chlorpromazine, diethazine, dimethothiazine, mequitazine, mesoridazine, piperacetazine, prochlorperazine, promethazine, propiomazine, thiazinamium, thiopropazate, thioproperazine... 

Chlorpromazine, dimethothiazine, mesor-idazine, methdilazine, prochlorperazine, thiazinamium, thiopropazate... 

Apomorphine (— black), azatadine, benorylate, bisacodyl, buprenorphine, butriptyline, captodiame, chloro-pyrilene, chlorpromazine, clofazimine, codeine, diamorphine, diethylthiambutene, dihydrocodeine, dimeth-indene blue), dimethoxanate, doxorubicin, doxylamine, ethopropazine, ethoxazene, guaiphenesin, guanoxan, hexocyclium methylsulphate, mepyramine, 6-monoacetylmorphine, morphine, nalorphine, nor-morphine, oxprenolol, oxyphenisatin, pecazine, penthienate, perazine, perphenazine, phenoxybenzamine, phenyltoloxamine, pholcodine, pimozide, pipoxolan (-> grey), prochlorperazine, procyclidine, promazine, promethazine, proquamezine, solanidine, thenium, thiopropazate, tricyclamol, trimeprazine, viloxazine... 

Caution. Thiopropazate hydrochloride may cause severe dermatitis in sensitised persons. 

Infra-red Spectrum. Principal peaks at wavenumbers 1222,1728, 746,1265,1250,1200 (thiopropazate hydrochloride, KBrdisk). 

Dose. Initially 15 to 30 mg of thiopropazate hydrochloride daily maximum of 100 mg daily. 

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