Thiols microbial production

Rev-Eyes daplprazole. reviparin sodium [ban, inn] is a (parenteral) ANTICOAGULANT that is chemically a low-molecular weight form of heparin. It can be used therapeutically in the treatment of deep vein thrombosis, rexostatine (proteinase inhibitor E 64 E-64) is a microbial product isolated from AspergillusJaponicus. It is a (thiol) PROTEASE INHIBITOR, and can be used to sensitize lung and colon carcinomas to ANTICANCER chemotherapy. 

While this may be true for 3-mercaptoproplonate, the actual Importance of these reactions relative to microbial production of thiols can only be properly assessed with tracer experiments using radiolabelled substrates and reactants. 

Cell extracts of the protozoan Tetrahymena thermophila carry out the methylation of sulfide and selenide to methyl sulfide and methyl selenide (Drotar et al. 1987a), and the importance of microbial reactions in its synthesis has been examined (Drotar et al. 1987b). The environmental significance of the production of methyl sulfide has already been noted in Section 4.1.2. Aromatic thiols are also S-methylated by T. thermophila (Drotar and Fall 1986) as well as by Euglena gracilis (Drotar and Fall 1985). 

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