Thiethylperazine

Donnison, G.H. U.S. Patent 2,876,225 March 3, 1959 assigned to Abbott Laboratories 

Chemical Name 2-(Ethvlthio)-10-[3-(4-methvl-1 -piperazinvDpropvH phenothiazine Common Name — 

Torecan Torecan Torecan Torecan T orecan Toresten 

3-Ethy I mercapto-phenothiazine 1 -Methyl-4-(3 -chloropropyl-1 )-piperazine Sodium amide 

Upon the addition of ethanolic HCI to a solution, cooled to 0°C, of 26.38 parts of the free base in 130 parts by volume of absolute ethanol, until a Congo-acid reaction is achieved, the crystalline dihydrochloride of 3-ethylmercapto-10-[3 -(1 -methyl-piperazyl-4 )-propyl-1 ] -phenothiazine is precipitated. The analytically pure salt has a melting point of 214°C to 216°C (bubbles) it begins to sinter at 205°C. The dimaleate melts at 188°C to 190°C after sintering from 180°C (recrystallized from methanol). 

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C14H14CI2N2O2 16390-18-4) see Indometacin 4-chlorobenzoic acid methyl ester (C8H7CIO2 1126-46-1) see Moclobemide 2-chlorobenzoic add potassium salt (C7H4CIICO2 16463-38-0) see Thiethylperazine... 

C (H 7C1N2 104-16-5) see Butaperazine Perazine Prochlorperazine Thiethylperazine Thioproperazine Trifluoperazine... 

Blue, violet benperidole imiclopazine thiethylperazine thioridazine i... 

Blue, violet benperidole dihydroergotamine imiclopazine levomepromazine thiethylperazine thioridazine )... 

Chlorpromazine (Thorazine) Chlorpromazine suppository Prochlorperazine (Compazine) Prochlorperazine suppository Promethazine (Phenergan) Thiethylperazine (Torecan)... 

Rizk et al. [3] used 2,3-dichloro-5,6-dcyano-/)-benzoquinone as a redox titrant in the aqueous titration of penicillamine. Finely ground tablets were mixed with H20 and the mixture was filtered. The filtrate (or an injectable solution) was diluted with H20 and acidified with H3PO4 before titration with the redox titrant. The titration was conducted in anhydrous acetic acid using thiethylperazine dihydrochloride as the indicator. The endpoint was detected by a color change to green, and recoveries of penicillamine were 98.4-100.5%. 

Thiazinone, synthesis, 280 Thiazosulfone, 141 Thiethylperazine, 382 Thiobarbital, 275 Thiofuradene, 231 Thiopental, 274 Thiopropazate, 383 Thioridazine, 389 Thiothixene, 400 Thonzylamine, 52 Thrombosis, 397 Thyroid gland, 95 Thyroxine, 95, 97 Tolazamide, 137 Tolazoline, 241 Tolbutamide, 136 Tolycaine, 17... 

THIETHYLPERAZINE Do not use IV (may cause severe hypotension). Use of this drug has not been studied following intracardiac or intracranial surgery. 

Phenothiazines are antipsychotic agents that can be used for their potent antiemetic and sedative properties (see Chapter 29). The antiemetic properties of phenothiazines are mediated through inhibition of dopamine and muscarinic receptors. Sedative properties are due to their antihistamine activity. The agents most commonly used as antiemetics are prochlorperazine, promethazine, and thiethylperazine. 

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