Thiazolyl urea alkylation

Alkylation of bis(4-methyl-2-thiazolyl)urea (257) with dimethyl sulfate gives product 258 dimethylated on the ring nitrogens (Scheme 154) (488). Alkylation of l-alkyl-3-(2-thiazolyl)urea from its derived anion formed by NaH gives 259 (Scheme 155). 

Isocyanate, Me, 431 phenyl, 431 Isocyanates, 58 acyl isocyanates, 92 alkyl isocyanates, 92, 118 aryl versus alkyl, 118 with hydrazinothiazoles, 100, 106 with 2-imino-4-thiazolines, 125 to mesoionic compounds, 65 to thiazolyl urea, 58, 92 Isoindolenine derivative, 56 Isomerism, E-Z equilibrium, 23 Isomerization, catalyst in aji-unsaturated acids, 438... 

Niridazole Niridazole, l-(5-nitro-2-thiazolyl)-2-imidazolidinone (38.1.11), is made by reacting 2-amino-5-nitrothiazol with 2-chloroethylisocyanate to make the disubstituted urea (38.1.10). Heating this compound results in an intramolecular N-alkylation reaction to form the desired imidazolidine derivative, niridazole [7-11]. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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