Thiazoles, cross-dehydrogenative coupling with

Scheme 51 Cu-catalyzed cross-dehydrogenative coupling of (benzo)thiazoles with cyclic ethers.

Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions of (benzo)thiazoles 49 with cycHc ethers 50 have been developed under mild conditions (130L4600). Notably, the 2-thiazolyl acetals, known as the masked 2-thiazolecarboxaldehydes, could be successfully obtained by this CDC reaction. 

Copper-catalyzed dehydrogenative cross-coupling reactions of (benzo) thiazoles with cychc ethers 106 to give the products 107 have been developed by Jiang and Chen (Scheme 51) (20120L4950, 20130L4600). A radical pathway was proposed for the reaction with cyclic ethers initiated... 

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