Thiazole structure

In 1887, Hantzsch and Weber (1) confirmed the thiazolic structure of the so-called isothiocyanoacetic acid (38). 

Erlenmeyer and Schmid (459), in the course of a fundamental comparison between pyridine and its isosteric thiazole structures, prepared the... 

The pyrolysis thresholds of this series of compounds show that the thiazole structure is thermostable, decomposition temperatures being generally between 450 and 510°C. Other observations that can be made are ... 

The chemistry of mononuclear isothiazoles has been developed since 1956 without the aid of thiohydroxylamine, the preparation of this very unstable substance having only recently been reported. Bicyclic and polycyclic systems involving the isothiazole (1,2-thiazole) structure have long been known and were fully reviewed in 1952, but little new work has been reported since then and the present review... 

Although thiazoles structurally resemble imidazoles and oxazoles, they are less reactive with electrophiles. Calculated 7r-densities (48BSF1021) and localization energies (61CCC156) largely agree with experimental observations that positional specificities for electrophilic substitution are 5... 

Starting thiazole structure prederived from cysteine and acetate. The impressive cytotoxicity of these structures has given rise to a flurry of interest in their total synthesis which was first performed for both 82 and 81 by Danishefsky and co-workers [123,124]. 

Febuxostat 88 is an inhibitor of xanthine oxidase that has been developed by Teijin Pharma as a new drug for the treatment of gout and hyperuricemia [62]. The 2-aryl-thiazole structure is prepared by Teijin via a condensation between 2-chloroacetate 83 and arylthioamide 82 (Scheme 20a) [63]. However, Cipla, a... 

Similarly to synthesis of fluorinated oxazoles the methods of preparation of fluorine-containing thiazoles may be subdivided into two synthetic approaches incorporation of fluorine atom or fluoroalkyl groups in thiazole structure, and the synthesis based on fluorinated building blocks. 

---