Thiazole 2-methoxy

Thiazole, 2-methoxy-4-methyl-kinetic data, 6, 255 (75JCS(P2)1614)... 

Thiazole, 4-isopropyl-2,5-dimethyl-quatemization, 6, 254 Thiazole, 2-lithio-reactions, 5, 106 6, 292 4-substituted synthesis, 6, 305 Thiazole, 2-mercapto-4-phenyl-synthesis, 6, 300 Thiazole, 4-mercapto-2-phenyl-tautomerism, 6, 291 Thiazole, 5-mercapto-2-phenyl-tautomerism, 6, 289 Thiazole, 2-methoxy-reactions, 5, 102 rearrangement, 6, 289 Thiazole, 2-methyl-anions... 

The reaction of MeO /MeOH with 2-Cl-5(4)-X-thiazoles (122) follows a second-order kinetic law, first order with respect to each reactant (Scheme 62) (297, 301). A remark can be made about the reactivity of the dichloro derivatives it has been pointed out that for reactions with sodium methoxide, the sequence 5>2>4 was observed for monochlorothiazole compounds (302), For 2.5-dichlorothiazole, on the contrary, the experimental data show that the 2-methoxy dehalogenation is always favored. This fact has been related to the different activation due to a substituent effect, less important from position 2 to 5 than from... 

Methoxythiazole has been prepared by the Williamson reaction. The methoxy group exerts a bathochromic effect on the 233-nm band of the thiazole and shields both C-2H and C-5 H (0.67 and 0.89 ppm) (289). 

Some Hammett values for reactions in thiazole and in nucleophile are reported in Table V-3. The observed p values for normal substitution processes (methoxy and thiophenoxysubstitution) are high and positive, indicating that the substituent plays an important role in modifying the stability of the intermediate anion. 

N,N-Diacyl-thiohydroxylamine werden durch Natrium-bis-[2-methoxy-athyl]-dihydrido-aluminat in Benzol mit guten Ausbeuten zu Aldehyden reduziert. Mit Hilfe von 3-Oxo-2,3-dihydro-(benzo-[d]-l,2-thiazol)-l,l-dioxid gelingt es auf diese Weise Car-bonsaure-chloride auf einfache Weise in Aldehyde zu iiberfiihren z. B.2 ... 

Aldehyde allgemeine ArbeitsvorschrifL Zu einer Suspension von 1 Mol 3-Oxo-2-acyl-2,3-dihydro-(ben-zo-[d]-l,2-thiazol)-l,l-dioxid in abs. Benzol wird unter Riihren und unter Stickstoff cine Losung von 0,5 Mol Natrium-bis-[2-methoxy-athoxy]-dihydrido-aluminat in abs. Benzol bei 0-5° innerhalb 5—10 Min. in kleinen Portionen gegeben. Man riihrt 2 Stdn. bei dieser Temp., vcrsetzt mit Wasser, saugt den Niederschlag ab, wascht mit Benzol nach, schiittelt die waBr. Phase mit Benzol aus, und dampft nach Trocknen die Benzol-Losungen ein. Der Riickstand wird destilliert bzw. kristallisiert. 

As compounds exhibiting enhancing effects on CL reactions, a variety of phenols, e.g., firefly luciferin and 6-hydroxybenzothiazole derivatives [12,13], 4-iodophe-nol [14], 4-(4-hydroxyphenyl)thiazole [15], 2-(4,-hydroxy-3 -methoxy-benzyli-dene)-4-cyclopentene-l,3-dione (KIH-201) [16], and 2-(4-hydroxyphenyl)-4,5-diphenylimidazole (HDI) and 2-(4-hydroxyphenyl)-4,5-di(2-pyridyl)imidazole (HPI)[17] (Fig. 6A), and phenylboronic acid derivatives, e.g., 4-phenylylboronic acid [18], 4-iodophenylboronic acid [19], and4-[4,5-di(2-pyridyl)-l //-imidazol-2-yl]phenylboronic acid (DPPA) [20] (Fig. 6B), in the luminol/hydrogen peroxide/peroxidase system are well known. Rhodamine B and quinine are used as sensitizers in the CL-emitting reaction between cerium (IV) and thiol compounds. This CL reaction was successfully applied to the sensitive determination of various thiol drugs [21-32],... 

The synthesis of other biologically active thiazoles was described by Ohsumi et al. [50] and is shown in Scheme 16. Condensation of phosphonium bromide and 4-methoxy-3-nitrobenzaldehyde gave a 1 1 mixture of (Z)- and (-E)-stilbenes. ( )-stilbene 64 was purified by crystallization and then converted to bromohydrin 65 by NBS-H2O. Oxidation of the bromohydrin by DMSO-TFAA gave the bromoketone intermediate 66, which was condensed with thiocarbamoyl compounds in the presence of Na2C03 in DMF to give the corresponding 2-substituted thiazole derivatives (67a and b). Compound 67a... 

More recently, another cyanobacterium belonging to Lyngbya genus, L. bouillonii, has been shown to contain a new tetrapeptide, lyngbyapeptin A (427), which contains the rare 3-methoxy-2-butenoyl moiety and a thiazole ring [333]. 

Increments for a larger number of substituents in various positions permit 13C shift predictions of pyrroles [435], thiazoles [437], indoles [445], and pyridines [452], Similarly to benzene, substituted carbon shifts essentially are related to substituent electronegativity, while ortho- and para-like carbons are predominantly affected by mesomeric (resonance) effects of donor (( — )-M) or acceptor substituents as shown for methoxy... 

Propanoic Acide 2-Benzoylamino-2-(4-methoxy-benzyl)-3,3.3-tri-fluoro- E10b2, 180 (subst. 5-Oxo — 4.5-112 1,3-thiazole/HCl)... 

Butyl-4-iso butyl-5-- methoxy thiazole i2-C4H9 j-C4H9 och3... 

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