Thiamin vitamin analogs

Lipid soluble analogs of thiamine (vitamin Bj) 1126 have a number of therapeutic uses, and examples are acetiamine 1127 (R = Me), bentiamine 1127 (R = Ph), fursultiamine 1128, and octotiamine 1129 which has antiinflammatory activity. 

Thiamin 0.23 mg or more per 1000 kcal of food consumed and a minimum total of 0.8 mg/day. Replacement of the methyl group on the pyrimidine ring by ethyl, propyl, or isopropyl gives compounds with some vitamin activity, but replacement by hydrogen cuts activity to 5% of the original. The butyl analog is a competitive inhibitor. 

Dwivedi and Arnold (89) determined the thiazole moiety in thiamine by derivatizing first to form the TMS analog. Samples were chromatographed on 3% OV-17 on Chromosorb G (DMCS treated) at 110°C. Vitamin D2 (calciferol) and its analog Vitamin have been the subject of many applications in GC analyses. The compounds have been derivatized as the TMS analog and chromatographed on OV-17 (90) and SE-30 (91) and on 3% silicone on Celite after treatment with antimony trichloride (92). Several references to vitamine E (oi-tocopherol) are included in the review by Kern et al. (39) on GLC determinations of pharmaceuticals and drugs. The acetate was determined on 3% OV-17 on Chrom W-HP at 280°C. Vecci and Kaiser (93) determined Vitamin C as the TMS derivative on 3% SE-30 or 10% XE-60 on Anachrom ABS. Column... 

The catalytic activity of thiazolium salts in aldehyde dimerization has an analogy in nature the action of thiamine, or vitamin Bj. Thiamine, in the form of its pyrophosphate, is a coenzyme for several biochemical transformations, including the breakdown of the sugar glucose (Chapter 24). 

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