Vitamin E analogs

Osakada F., Hashino A., Kume T., Katsuki H., Kaneko S., and Akaike A. (2004). a-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47 904-915. 

Figure 4.1. Vitamin E vitamers, tocopherois and tocotrienois, and the synthetic water-soluble vitamin E analog, Trolox. Relative molecular masses (Mr) a-tocopherol, 430.7 (acetate 488.8, succinate 546.8) , 6-tocopherol, 419.7 y-tocopherol, 416.7 5-tocopherol, 402.7 a-tocotrienol, 424.7 , 6-tocotrienol, 410.7 y-tocotrienol, 410.7 5-tocotrienol, 396.7 and Trolox, 250.3.

HosomiA, Arlta M, Sato Y, Kiyose C, UedaT, Igarashi O, Aral H, and InoueK (1997) Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Letters 409,105-8. 

Hosomi, A., Arita, M., Sato, Y., Kiyose, C., Ueda, T., Igarashi, O., Arai, H., and Inoue, K. 1997. Affinity for Alpha-Tocopherol Transfer Protein as a Determinant of the Biological Activities of Vitamin E Analogs. FEBS Lett. 409 105-108. 

Cells incubated with different natural or synthetic vitamin E analogs show striking differences in cellular responses since most of the synthetic analogs of vitamin E cannot act as antioxidants, and the natural tocopherols have essentially equal antioxidant activity, such differences can only be explained by specific non-... 

Potent inhibitory actions have also been observed with the aglycone flavonoids, kaempferol and quercetin, (>95% inhibition), whereas rutin, catechin, esculetin, and the water-soluble vitamin E analog, Trolox, were without effect (14) (Table 1). These experiments provide further indirect evidence that the contracting factor(s) that mediate the abnormal spontaneous contraction are free radical and/or secondary products of the COX pathways (COX-l/COX-2). Although all of these... 

CHAUMONTET, C., BEX, V, VERAN, F. MARTEL, P. 2008. The vitamin E analog tocopherol succinate strongly inhibits gap junctional intercellular communication in rat liver epithehal cells (IAR203). J Nutr Biochem, 19, 263-8. 

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