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1.3.4- Thiadiazolium-2-aminides

Several l,3,4-thiadiazolium-2-aminides were also tested against pro-mastigote and amastigote forms of Leishmania amazonensis. Parasites were assayed with or without the drugs in axenic media, using pentamidine isethionate as a reference drug. The most active compounds were the... [Pg.149]

A parallel solid-phase synthesis of l,3,4-thiadiazolium-2-aminides involves trimethylsilyl chloride mediated cyclization of resin bound aldehydes 269 and 1,4,-disubstituted thiosemi-carbazides 268 <04JCO746>. Two additional combinatorial approaches have been developed to prepare focused libraries of 1,3,4-thiadiazoles <0478627 04BBR1053>. 1,3,4-Thiadiazoles 273 are prepared by condensation of triazole 271 with various carboxylic acids 272 in the presence of phosphorus oxychloride <04IJHC69>. [Pg.220]

See other pages where 1.3.4- Thiadiazolium-2-aminides is mentioned: [Pg.135]    [Pg.135]    [Pg.136]    [Pg.137]    [Pg.245]    [Pg.435]    [Pg.135]    [Pg.135]    [Pg.136]    [Pg.137]    [Pg.137]    [Pg.245]    [Pg.435]   
See also in sourсe #XX -- [ Pg.137 , Pg.149 ]



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1,3,4-Thiadiazolium

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