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Thermosensitive Poly organo phosphazenes

6 Thermosensitive Poly(organo)phosphazenes 3.6.1 Thermosensitive Poiymers [Pg.108]

Figure 3.28 Viscosity profile showing the reversible gelation behaviour of a DOX-loaded thermosensitive poly(organo) phosphazene at various concentrations. Reproduced with permission from G.D. Kang, S.H. Cheon and S.C. Song, International Journal of Pharmaceutics, 2006, 319, 1-2, 29. Figure 3.28 Viscosity profile showing the reversible gelation behaviour of a DOX-loaded thermosensitive poly(organo) phosphazene at various concentrations. Reproduced with permission from G.D. Kang, S.H. Cheon and S.C. Song, International Journal of Pharmaceutics, 2006, 319, 1-2, 29.
Similar thermosensitive poly(organo)phosphazenes have also been assessed in combination with camptothecin [178], 5-fluorouracil [179] and silibinin [180], as well as the breast cancer drug 2-m ethoxy estradiol [181], thus proving to be a versatile, effective and safe delivery system. Furthermore, as well as the delivery of standard, lipophilic chemotherapeutic agents, the approach has been extended to other, noncancer therapies, for example, injectable polyplex hydrogels for the localised and long-term delivery of siRNA (discussed in Section 3.2.2) and growth hormone delivery. [Pg.115]

Some of the micellar and polymersome structures based on poly(organo)phosphazenes discussed in Section 1.5.4, which by their nature are amphiphilic, have also been reported to show thermosensitive behaviour, that is to aggregate into nanoscale structures upon surpassing their LCST in water. For example,... [Pg.109]

See other pages where Thermosensitive Poly organo phosphazenes is mentioned: [Pg.109]    [Pg.111]    [Pg.112]    [Pg.112]    [Pg.117]    [Pg.109]    [Pg.111]    [Pg.112]    [Pg.112]    [Pg.117]    [Pg.86]    [Pg.93]    [Pg.113]   


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