Thermoresponsive nanogel

Hoare T, Young S, Lawlor MW, Kohane DS. Thermoresponsive nanogels for prolonged duration local anesthesia. Acta Biomater. 2012 8 3596-3605. 

Wong, J. E., Muller, C. B., Diez-PascuaL A. M., Richtering, W. J. Study of layer-by-lay er films on thermoresponsive nanogels using temperature-controlled dual-focus fluorescence correlation spectroscopy. J. Phys. Chem. B 2009,113, 15907-15913. 

Recently, Liu s group also reported the fabrication of thermoresponsive cross-linked hollow poly(A-isopropylacrylamide) (PNIPAM) nanocapsules with controlled shell thickness via the combination of surface-initiated atom transfer radical polymerization (ATRP) and click cross-linking. Cross-linked PNIPAM nanocapsules were fabricated by the click cross-linking of PNIPAM shell layer with a tri-functional molecule, l,l,l-fm(4-(2-propynyloxy) phenyl)ethane. Due to the thermo-responsiveness of PNIPAM, cross-linked PNIPAM nanocapsules exhibit thermo-induced collapse/swelling transitions that make it possible to classify them as nanogels. 

The fabrication of thermoresponsive PG nanogels was recently developed by Calderdn et al. [35] in an attempt to develop stimuli-responsive materials based on dendritic PG. In this work, the precipitation polymerization method... 

Wu L, Zhou H, Sun HJ, Zhao Y, Yang X, Cheng SZ, Yang G (2013) Thermoresponsive bacterial cellulose whisker/poly(NIPAM-ct>-BMA) nanogel complexes synthesis, characterization, and biological evaluation. Biomacromolecules 14 1078-1084... 

The thermoresponsiveness of PPE with a specific chemical structure can also be used for the convenient fabrication of nanoparticles, which can be used as carriers of chemotherapeutic drugs for cancer therapy. Biodegradable nanogels based on PPEs with tunable sizes have been synthesized by a... 

FIGURE 6.9 Temporal stability of LbL-coated nanogels in water over different periods of time (a) NG/PLL (b) NG/(PLL/PGA) (c) NG/CHIT (d) NG/(CHIT/DEX). Gels coated with polysaccharide layers are reversibly thermoresponsive, and for clarity, only the heating cycles are shown. Reprinted from Ref. [20], copyright 2010, with permission from Elsevier. 

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