Therapy in Nursing Mothers

FIGURE 22.7 Kinetic analysis of theophylline plasma ( ) and milk (a) concentrations after intravenous administration of a 3.2- to 5.3-mg/kg aminophylline dose. The lines represent the least-squares fit of the measured concentrations. The interval and volume of each milk collection are shown by the solid bars. The milligram recovery of theophylline in each breast-milk collection is shown by the numbers above the bars. (Reproduced with permission from Stec GP et al. Clin Pharmacol Ther 1980 28 404-8.) 

Drug (and metabolite) Protein binding (%) M/P Infant dose (%) Detectable in infant plasma Reported infant toxicity Ref. 

Abbreviations M/P = ratio of concentrations in maternal milk and plasma, NE = norepinephrine. 

Zinacef (cefuroxime) labeling, in Physicians Desk Reference, 54th ed. Montvale, NJ Medical Economics 2005. p. 1678. 

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