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Therapeutic injections multiple dose

A 66-year-old man with radiation-induced aplastic anemia and myelodysplastic features failed to respond to multiple therapeutic regimens. A trial of recombinant human interleukin-3 was begun, but he had transient shortness of breath and hypotension after the first subcutaneous injection. On the next day, 2 hours after the second dose, he had restlessness, dyspnea, spasticity, wheezing, cyanosis, hyperthermia, tachycardia, and hypotension (70/50 mmHg). Full recovery was obtained with fluids, adrenaline, promethazine, and glucocorticoids. [Pg.1844]


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See also in sourсe #XX -- [ Pg.1266 ]




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