Therapeutic environmental impacts

Many factors affect the process design for manufacturing therapeutic proteins they include protein type and size, production scale, and the type of host cells used. The environmental impact considerations are focused on two major groups nonantibody proteins produced by microbial cells and mAbs produced by mammalian cells. 

As a complex disorder with multifactorial clinical features, Alzheimer s disease (AD) needs to be studied in the context of diverse environmental impacts, cerebrovascular dysfunction, epigenetic phenomena, as well as various structural and functional genomic dysfunctions (see Chapter 13). This book provides a comprehensive and detailed discussion of the pharmacogenomics of AD, from functional genomics to therapeutic strategies, from the discovery of reliable biomarkers to the optimized drug development. 

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