Proxyphylline theophylline

Hydroxypropyl)theophylline (Proxyphylline) [603-00-9] M 238.2, m 135-136 . Crystd from EtOH... 

The already mentioned influence of the pH of the buffer on the retention of 8-chlorotheophylline was investigated by Hill64, who found that an optimum separation of xanthine derivatives was obtained at a pH of 5.0 for a mobile phase consisting of 1% propionic acid - methanol (8 2) on an octadecyl column. For a simultaneous analysis of theophylline, proxyphylline and... 

Hydroxypropyl)theophylline (Proxyphylline, l,3-dimethyl-3H,7H-purine-2,6-dione) [603-00-9] M 238.2, m 135-136°. Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]... 

The diffusion behaviour of low molec.wt. drugs (theophylline, proxyphylline and oxprenolol.HCl) from pH-sensitive, anionic, initially glassy copolymer networks of 2-hydroxyethyl methacrylate with acrylic acid and/or methacrylic acid was studied as a function of pH, ionic strength and the nature of the dissolution medium. The dissolution media used were simulated physiological fluids such as simulated gastric fluid, a phosphate buffer of pH 7.4 and a glutarate buffer solution of pH 7.19 refs. USA... 

A significant size exclusion phenomenon was observed for the IPN membranes. Theophylline R =1.3 A), proxyphylline = 2.3 A), ox-prenolol HCl R = 2.6 A), and FITC-Dextran R = 49 A) were used as model drugs in the diffusion study where R denotes the hydrodynamic radius of the solute. The solute size, membrane mesh size, pH, temperature, and the affinity of the solute with the membrane can affect the permeation of the solute. 

Figure 6 Solute permeation of theophylline (O), proxyphylline ( ), oxprenolol HCl (A), and FITC-Dextran (V) through PMAA/PNIPAAm IPN. The slope represents the permeability of each solute.

Mosbech H, Paulsen H, Soborg M. Controlled-release theophylline and proxyphylline in asthmatics a comparative study. Pharmatherapeutica 1984 3(9) 626-30. 

Column pBondapak C18 (300x3.9 mm ID), mobile phase methanol - 0.02 M aqueous potassium chloride (pH 2 adjusted with hydrochloric acid)(3 7), flow rate 1.6 ml/min, detection UV 280 nm. Peaks 1, theobromine 2, theophylline 3, proxyphylline 4, caffeine 5, 8-chlorotheophyl-line xl and x2 are unidentified compounds constantly present in serum, (reproduced with permission from ref. 68, by courtesy of Acta Pharmacologica et Toxicologica)... 

Proxyphylline. 3,7-Dihydro-7-(2-hydroxypropyl -I,3-dimethyl-l H-purine-2,6-dione 7-( 2-hydroxy propyl lhe-ophylline Brontyl Proxy-Retardoral Purophyllin Spantin Spasmolysin Thean Theon. C H N O,. mol wt 238.24. C 50.42%, H 5.92%. N 23.52%, D 20.15%. Prepd by refluxing l-chloro-2-propano] witb theophylline in an alkaline medium Rice, U.S. pat. 2,715,125 (1955 to Gene s Chem, Works). 

Wenk, M. Eggs, B. Follath, F. Simultaneous determination of diprophylline, proxyphylline and theophylline in serum by reversed-phase high-performance liquid chromatography. J.Chromatogr., 1983, 276, 341-348... 

A few typical examples of the members of this category are caffeine, theophylline, theobromine, aminophylline, etofylline and proxyphylline. 

Xanthine derivatives Oral Aminophylline, Bamifylline, Bufylline, Choline theophyllinate, Diprophylline, Doxofylline, Etofylline, Etamiphylline camsilate, Heptaminol acefyllinate, Proxyphylline, Theophylline... 

ICI 58 301 (3-acetamldo-6-methyl-8-n-propyl-8-triazolo [4,3-a] pyrazine) is a new compound that is a greater inhibitor of phosphodiesterase than theophylline In animals, ICI 38 301 is far more powerful in preventing bronchospasm than in acting as a bronchodilator. This activity has been confirmed in asthmatic patients . Proxyphylline, 7-(2-hydroxy-propyl) theophylline, administered as a suppository (500 mg) is effective in enhancing pulmonary function in chronic asthmatic patients . ... 

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