Their Receptors in MS

Similarly, elevated CCR5 in activated macrophages was found in MS lesions, indicating RANTES might mediate the recruitment and activation of monocytes and macrophages in MS (Sorensen et al., 1999). Further, MCP-1, MCP-2, MCP3, MIP-la, and MIP-lp immunoreactive ash ocytes within MS lesions have been described (McManus et al., 1998 Simpson et al., 1998 van der Voom et al., 1999 Boven et al., 2000). These results were support by the study in the EAE model, particularly MCP-1 (Ransohoff et al., 1993 Berman et al., 1996), IP-10 (Ransohoff et al., 1993), RANTES (GocUska et al., 1995). 

Taken together, these results indicate extensive chemotactic interactions betw een the gha cells in MS lesion and the infiltrating cells. Whether these interactions ultimately promote destructive inflammation or recruitment of viral and protective regulatory cells that enhance tissue repair is still not clear. This is a crucial question to answer before potential pharmacological intervention based on chemokines and their receptors could be reinforced for the treatment of the MS. 

---