Thebaine Oxymorphone

Oxymorphone Oxymorphone, 4,5-epoxy-3,14-dihydroxy-N-methyl-6-oxyomorphinane (3.1.26), is chemically similar to hydromorphone. It differs from hydromorphone in that it contains a hydroxyl group on C13. The drug is synthesized from thebaine (3.1.23), which during oxidation with hydrogen peroxide in formic acid changes into 14-hydroxycodeinone... 

The most known narcotics are the opium alkaloids such as morphine, codeine, thebaine, papaverine, noscapine and their derivatives and modified compounds such as nalmorphine, apomorphine, apomopholcodine, dihydrocodeine, hydro-morphone and heroine, also known as diamorphine. Synthetic narcotics share the structural skeleton of morphine and include dextromethorphan, pentazocine, phenazocine meperidine (pethidine), phentanyl, anfentaitil, remifentalin, methadone, dextropropoxyphene, levoproxyphene, dipipanone, dextromoramide, meptazinol and tramadol. Thebaine derivatives are also modified narcotics and include oxycodone, oxymorphone, etorphine, buprenorphine, nalbuphine, naloxone or naltrexone. Narcotics can be semi-synthesized or totally synthesized from the morphine and thebaine model. The compounds serve various purposes in clinical practise. 

After 10 years of intensive research, no significant dissociation of potent analgesia and dependence liability was accomplished. As an indirect result of the systematic program the identification of the 17-hydroxy-7,8-dihydro compounds oxycodone (patented in 1925 by E. Merck AG, Germany) and oxymorphone, derived from thebaine, are of particular note. 

EN 1639A UM 792 Nalorex " Trexan ) is one of the phenanthrene series and an analogue of oxymorphone and thebaine, and is also an analogue of the antagonist naloxone. It is a (largely subtype-unselective) opioid RECEPTOR antagonist, and is used orally in detoxification treatment for formerly opioid-dependent individuals to help prevent relapse. 

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