The use of solid-supported reagents in noncatalytic flow processes

5 The use of solid-supported reagents in noncatalytic flow processes 

From the examples above it can be seen that the incorporation of solid-supported catalysts into flow reactors can afford extremely efficient processes however, recently numerous authors have reported the use of 

To synthesize a series of organic azides, the authors pumped a solution of the acyl chloride (1.0M in MeCN) through the azide monolith 177, at room temperature (0.5 ml min-1), to afford a residence time of 13 min. In the case of the substrate 3-bromobenzoyl chloride, removal of the reaction solvent in vacuo afforded the respective azide, 3-bromobenzoyl azide, in quantitative yield and excellent purity. Having demonstrated the successful conversion of acyl chlorides to acyl halides, the next step of the investigation was to decompose the acyl azide under flow, in situ, to afford the respective isocyanate. 

---