The role of glutamate uptake in synaptic transmission

In order to understand the transmission at glutamatergic synapses, which represent the majority of the excitatory synapses in the CNS (Ottersen and Storm-Mathisen, 1984), it is necessary to understand how the concentration of glutamate changes after synaptic release. 

Although significant progress has been made in recent years, essential pieces of information are still lacking. This includes information on the amount of glutamate released (see below) and on the densities of EAAC and the nerve terminal glutamate transporter. 

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