The quest for macromolecular sequences

On the basis of what was said earlier about copolymerization theory, these results cannot be generalized for the case of co-oligopeptides. 

In particular, the aminoacyl phosphate derivatives of 5 -AMP could condense to a polypeptide containing up to 56 residues. This is certainly a very elegant and impressive reaction, hut its relevance from the point of view of prebiotic chemistry is doubtful since, as already mentioned, it is not obvious whether and to what extent this reaction can be extended to co-oligopeptides. Also, of course, AMP cannot be considered (thus far) a prebiotic molecule. Here again we encounter the old problem of the RNA world, the fact that the prebiotic synthesis of mononucleotides is not understood. There is no doubt that if a robust and credible prebiotic route 

Still with the prebiotic scenario, the conditions developed by Limtrakul et al. (1985) are interesting as a consequence of evaporation, high local concentrations may have arisen, and under such conditions the incompletely hydrated metal ions may activate a dehydration leading to peptide condensation. From this, the technique of the salt induced peptide condensation (SIPC) has been developed (Oie et al, 1983 Suwannachst and Rode, 1999 Rode et al, 1999). 

There is some claim that long polypeptide chains may derive not so much from the condensation of amino acids, but from the polymerization of HC N followed by simple prebiotic chemistry to mould the side chains (Matthews, 1975) however, this theory has not yet found great support in the field. 

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