The Origins of Multidimensional Chromatography

The main origin of multidimensional chromatography lies in planar chromatography. The development of paper chromatography, i.e. the partition between a liquid moving by capillary action across a strip of paper impregnated with a second liquid 

Most developments in the past two decades, however, have involved coupled column systems which are much more amenable to automation and more readily permit quantitative measurements, and such systems form the subject of this present book. A review on two-dimensional GC was published (43) in 1978 (and recently updated (29)), and the development by Liu and Phillips in 1991 of comprehensive 2D GC marked a particular advance (33). The fundamentals of HPLC-GC coupling have been set out (37) with great thoroughness by Grob. Other work on a number of other aspects of multidimensional chromatography have also been extensively reviewed (44,45). 

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