The Molecular Design of Polymeric Micelle Drug Carrier Systems

THE MOLECULAR DESIGN OF POLYMERIC MICELLE DRUG CARRIER SYSTEMS 

PEG-[poly(ethylene oxide)] has one of the lowest ratios (Mvy/Mn) because this substance is synthesized by anionic polymerization, which can produce polymers that have narrow molecular weight distributions. The ratios of PEG usually range from 1.05 to 1.20. In contrast, conventional radical polymerization, which is the most common way to produce S3mthetic polymers, produces polymers that have a wide distribution of molecular weight. Typically, polymers obtained in this way possess M /M ratios over 2.0. It is believed that block copol3uners with narrow molecular distributions on each block are preferable for pol3rmeric micelle studies because the close relationships between the molecular architectures of block copolymers and the properties of micelles are easily analyzed using narrowly distributed block copolymers. 

Means of Drug Incorporation Chemical Conjugation and Physical Entrapment 

several physical factors of pol3rmeric micelles that determine drug targeting and therapeutic effects of carrier systems are discussed. Table 3 siunmarizes six physical factors of polymeric micelles. 

Tumor volume on day 12 post the first drug iiyection 

---