The Mizoroki-Heck Reaction on Solid Supports

Throughout this survey, the type of resin used in the different examples will be given. If not stated otherwise, the resin bead insignia symbolizes the terminal part of an aromatic substructure. 

The Mizoroki-Heck reaction can either be performed on immobilized aryl halides with soluble alkenes [13] or alkynes or with the latter being attached to solid phase and free aryl halides. When performed on the same type of resin and using identical catalyst cocktails, however, it generally seems preferable to use immobilized aryl halides with soluble alkenes rather than doing it the other way around [14]. Both possibilities have been reported and will be discussed below [11]. 

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Other major issues are the aspects of stereo- and regio-chemistry. Compared with its liquid-phase variant, where tremendous efforts have been made over recent years to develop chiral ligands and optimize procedures of enantio- and diastereo-selective syntheses of complex molecules, the Mizoroki-Heck reaction on solid supports is still in its infancy. Most libraries, indeed, contain racemates and mixtnres of diastereomers [11],... 

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