The Interplay of Mediators in Sepsis

inflammatory mediators of humoral and cellular origin are largely implicated in the development of sepsis and SIRS. These mediators, together with the inflammatory cells themselves, activate and damage the endothelial cells, which 

The authors are indebted to Sia Timmerman for her unfailing assistance in the preparation of the manuscript. We thank Paul Weise for providing photographic support and Bonno Hylkema, M.D., and Rend Brouwer, M.D., for their suggestions and careful review of the manuscript. 

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