The interleukins as haemopoietic growth factors

The IL family of cytokines have been discussed in detail in Chapter 5. IL-3 is perhaps the IL that figures most prominently in the haemopoietic process, and appears to stimulate not only 

CFU-GEMM, but also the precursor cells of basophils, eosinophils and platelets. The role of IL-11 has been discussed in Chapter 5. 

The interleukin family of cytokines has been overviewed in Chapter 9, and a number of cytokines are known to influence haemopoiesis. The IL-3 receptor, for example, is found on a wide variety of progenitor haemopoietic cells, and appears to stimulate not only CFU-GEMM, but also the precursor cells of basophils, eosinophils and platelets. The role of IL-11, which also plays a role, was also discussed in Chapter 9. 

Main producer cells Bone marrow stromal cell Macrophages Fibroblasts Lymphocytes Myoblasts Osteoblasts Monocytes Fibroblasts Endothelial cells Macrophages T-lymphocytes Fibroblasts Endothelial cells 

Main target cells Neutrophils. Also other haemopoietic progenitors and endothelial cells Macrophages and their precursor cells Haematopoietic progenitor cells Granulocytes Monocytes Endothelial cells Megakaryocytes T-lymphocytes Erythroid cells 

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