The Immunoproteome of H. pylori

TONI AEBISCHER, AEEXANDER KRAH , DIRK BUMANN, PETER R. JUNGBEUT , and THOMAS F. MEYER  

Honder march (ed), Proteomics Biomedical and Pharmaceutical Applications, 317—338. 

Immunoproteomics, i.e. the comprehensive identification of immunogenic proteins from an organism such as H. pylori, is an attractive approach to determine i) antigens that could be used to increase the sensitivity and specificity of non-invasive diagnostic tools based on serology and ii) vaccine candidates. Here we discuss the current information available on the H. pylori immunoproteome and its potential for application in vaccination or diagnosis. 

Further variability between strains will arise from differences in gene expression. Gene regulation appears to be comparably simple in H. pylori for which only three o-factors, six two component regulators and four transcriptional regulators are described (Aim and Tmst, 1999 Beier and Frank, 2000 Bereswill et al, 2000 Scarlato et al, 

These regulators may be complemented however by slipped-strand repair mechanisms leading to phase variation (see above) and differential methylation (Donahue et al, 2002). Studies investigating 

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