The Heptoglycan Domain in Helicobacter pylori Lipopolysaccharides

4-hnked GIcNAc (2) most prominently seven 3-substituted DD-Hep and three 

DD-Hep residue. The following structure may therefore be proposed for tlie Smith degradation products of MO 19 and 0 6 LPSs  

The LPSs from H. pylori MO 19 and 0 6 contained a single Le epitope at the nonreducing end of tlie LPS molecule wliich was attached through a Gal unit to a heptoglycan of 3-hnked oo-Hep units. These LPSs were also shown to have an inner core OS attached to Kdo representing tlie reducing terminus of the PS molecule from the LPS (Fig. 11). The backbone of tlie LPS core OS from these 

pylori were proven to be similar to those previously described for H. pylori type strain and P466 (Figs. 5 and 6). 

Studies on another H. pylori strain, serostrain 0 3, that also raised strain-specific antisera, yielded the polymeric Le O-chain units terminated by a Le or Le. as previously found in the elongated O-chains from H. pylori type strain and P466, respectively. The LPS of H. pylori 0 3 was also shown to earn a heptoglycan domain similar to tliat observed in strains MO 19 and 0 6. Hence. H. pylori 0 3 shared all the strnctural features present in strains previously discussed, namely, a polymeric fucosylated type-2 polyLacNAc O-chain and a heptoglycan region. 

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