The Enantioselective Toxicities of Polyaromatic Hydrocarbons PAHs

Several chiral polynuclear aromatic hydrocarbons (PAHs) pollute the environment, the most toxic of which include benzo(a)pyrene and anthracene derivatives, /6-naphthoflavone and so on. Of course, the toxic nature of PAHs has been known for a long time, but only a few reports are available 

8-dihydrodiol Weeks of promotion Percentage of mice with tumours Papillomas per mouse 

These studies have shown that benzo(a)pyrenes are not carcinogens as such, but that the carcinogenicity is developed due to their biotransformation into carcinogenic epoxide metabolites [51-56]. The two 

8- Sex dihydrodiol Number of mice witii pulmonary adenomas Percentage of mice with pulmonary adenomas Number of adenomas per mouse Number of mice with malignant lymphoma Percentage of mice with malignant lymphoma 

BP-epoxides Dose (nmoles) Papillomas per mouse Percentage of surviving mice with papillomas 

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