The Controls for Fatty Acid Metabolism Discourage Simultaneous Synthesis and Breakdown

The Controls for Fatty Acid Metabolism Discourage Simultaneous Synthesis and Breakdown 

The controls for fatty acid metabolism satisfy most of our expectations for what control systems should do. One of the most important aspects of control is that simultaneous syn- 

Similarly, factors that stimulate acetyl-CoA carboxylase, the first enzyme in the pathway for fatty acid synthesis, also discourage fatty acid catabolism. This dual effect occurs because the first enzyme in the pathway leads to the formation of malonyl-CoA, which is a potent inhibitor of carnitine acyltransferase I. This inhibition prevents the transport of fatty acids into the mitochondrion, thereby, preventing fatty acid breakdown. 

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