The Connection between Electron Transport and Phosphorylation

Compounds known as imcouplers inhibit the phosphorylation of ADP without affecting electron transport. A well-known example of an uncoupler is 2,4-dinitwphenol. Various antibiotics, such as valinomycin and gramicidin A, 

Note the difference in scale between part A and part B. The top arrows indicate the matrix side and F, subunit. The bottom arrow in part B indicates the intermembrane space. 

Repeating unit of valinomycin (Valinomycin is a cyclic trimer of four repeating units.) 

The coupling of electron transport to oxidative phosphorylation requires a multisuhunit membrane-bound enzyme, ATP synthase. This enzyme has a channel for protons to flow from the intermembrane space into the mitochondrial matrix. 

The proton flow is coupled to ATP production in a process that appears to involve a conformational change of the enzyme. 

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The connection between oxidation phosphorylation and electron transport is best described by... 

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