The Behavior of Proteins Enzymes, Mechanisms, and Control

Signals regulate the flow of traffic in much the same fashion as control mechanisms in chemical reactions. 

What is the concerted model for allosteric behavior What is the sequential model for allosteric behavior  

Does phosphorylation always increase enzyme activity  

How does the architecture of the active site affect catalysis  

How do the critical amino acids catalyze the chymotrypsin reaction  

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Chapter The Behavior of Proteins Enzymes, Mechanisms, and Control... 

In the following sections, we will discuss the influence of several reaction parameters such as temperature, degree of stirring, and the presence of gas/liquid surfaces on the deactivation behavior of proteins. Mechanisms of enzyme inactivation and aggregation are still poorly understood so, in the best case, the rate of activity loss can be correlated with system parameters such as surface area, power input, or collision frequency. However, the ability to control the resistance of an enzyme to inactivation due to exposure to elevated temperatures is essential for the understanding of thermophilic behavior and for developing rational approaches to enzyme stabilization. 

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