The Antioxidant Responsive Element and Phase II Gene Regulation

3 THE ANTIOXIDANT RESPONSIVE ELEMENT AND PHASE II GENE REGULATION 

Chemoprevention is a strategy used to block or suppress carcinogenesis and degenerative disease using dietary or pharmacological compounds. These chemo-preventive compounds include phenols [such as tm-butyl 4-hydroxyanisole (BHA), t-BHQ (active metabolite of BHA), ethoxyquine, curcumin (from turmeric) and resveratrol (from grapes)] and sulfur compounds [such as oltiplaz, sulforaphane 

Phase 1 enzymes Phase II detoxification aenes Phase III exporter 

Glutathione Peroxidase Superoxide Dlsmutase Catalase He m eoxy genase 

Pump out ABC transporters P-glycoprotein (MDR-1) multidrug resistant protein (MRP) 

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