That induce vascular changes

Figure 15-4 In silico subtraction method for mechanistic study to compare the hepatic gene expression profile induced by compound X to other compounds that induce hepatic APR secondary to inflammation at sites other than the liver. In the proposed simple model, compound X-induced gene expression change has two components. One is vasculitis specific the other is acute phase response (APR) specific. By subtracting the APR specific component, we might select candidate genes that are specifically associated with the hepatic vascular lesion Diclofenac known to induce APR without triggering vasculitis in liver is used to subtract genes activated by hepatic APR from the compound X response.

OKT3, an immunosuppressive monoclonal antibody, can induce systemic vascular changes (leaky syndrome) and prerenal azotemia, presumably by stimulating the release of cytokines (e.g., tumor necrosis factor). These effects are seen more often in poorly hydrated patients. There is also evidence that OKT3 may induce a direct tubular toxicity, since significant numbers of patients developing renal insufficiency also exhibit enzymuria. 

Interlobular capillaries are filled with thick, proteinaceous substances that are also deposited below the capillary endothelium and may even be found free in the interstitium. These changes are described as capillary sclerosis [68]. Although renal vascular changes in Balkan nephropathy have been pointed out as very important, they are not specific and can be encountered in other renal diseases. Ferluga et al. [70] and Sindjic [77] point out to similarities in early changes encountered in Balkan nephropathy with cyclosporine-induced nephrotoxic changes. 

Retinitis is usually believed to be one manifestation of the vascular changes associated with diabetes. A role of growth hormone has, however, been invoked in the pathogenesis of diabetic retinitis. Numerous reports have appeared claiming that diabetic retinitis is arrested by the establishment of spontaneous or induced hypopituitarism. Hypophysectomy has been... 

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