Thalitone - Chlorthalidone

Chlorthalidone (generic, Hygroton, Thalitone, combination drugs)... 

Oral 250, 500 mg tablets 250 mg/5 mL oral suspension Parenteral 500 mg for injection Chlorthalidone(generic, Thalitone, combination drugs) Oral 15, 25, 50, 100 mg tablets Demeclocycline(Declomycin)... 

Chlorthalidone has a long duration of action (48-72 hours) (see Table 27.3 for its other pharmacokinetic properties). Although quinethazone and metolazone are administered daily, chlorthalidone may be administered in doses of 25 to 100 mg three times a week. When chlorthalidone is formulated with the excipient povidone, the product. Thalitone. has greater bioavailability (>90%) and reaches peak plasma concentrations in a shorter time compared with its other products. Similar to the quinazolinones. it also is extensively bound to carbonic anhydrase in the erythrocytes. Chlorthalidone-induced effects on urine content and side effects are similar to those induced by thiazide diuretics. 

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