Tetrazoles hydroxy

Hydroxy tetrazole l-Hydroxy-5-azidotetrazole 5-Hydroxy tetrazole Hydroxy tetrazolylmethanol Hydroxytetrazolylmethanol Nitrate... 

The carboxylic function of active compounds has been changed to direct derivatives such as hydroxamic acids R— CO—NH—OH, acyl-cyanamides R—CO—NH—CN and acyl-sulfonamides R—CO—NH—SO2—R to planar acidic heterocycles such as tetrazoles, hydroxy-isoxazoles, etc., or even to non-planar sulfur- or phosphorus-derived acidic functions (Table 13.8). 

Azido hydroxy tetrazole (mercury and silver salts)... 

The 3-formyl group of 8-substituted 3-formyl-2-hydroxy-4//-pyrido[l,2-n]pyrimidin-4-one was reacted with (cyanomethyl)- and (terr-butoxycarbo-nylmethylene)triphenylphosphorane in THF, and with 5-aminotetrazole in boiling MeOH for 9h to yield ( )-3-propenenitrile, terr-butyl ( )-3-propenoate and 3-[(2//-tetrazol-5-yl)imino]methyl derivatives, respectively (OlMIPl). 

Reaction of 8-substituted 3-[2-(4-methoxybenzyl)-2//-tetrazol-5-yl]-4//-pyrido[l,2-u]pyrimidin-4-ones with CF3COOH for 2 days at room temperature gave 3-(2//-tetrazol-5-yl) derivatives (OlMIPl). The cyano group of a 3-(8-substituted 2-hydroxy-4-oxo-4//-pyrido[l,2-u]pyrimidin-3-yl)-2-propenenitrile was converted into a 5-tetrazolyl group by treatment with NaN3 in the presence of AICI3 in DMF at 100 °C for 2 days. 

CN [6i -[6a,7a,7(27 , 3 S )]]-7-[[2-[[(4-ethyl-2,3-dioxo-l-piperazinyI)carbonyl]amino]-3-hydroxy-l-oxobutyl]amino]-7-methoxy-3-[[( 1 -methyl- l//-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1 -azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid... 

Diazonium salts couple to hydroxy-substituted vicinal triazoles (101) with subsequent rearrangement of the hydroxy arylazo compounds (102) to the carbamoyl tetrazole (104).170 An open-chain intermediate (103) has been proposed.169 This rearrangement is similar to that of the benzoyl... 

Synthesis of ( )-trans-6-[4,4-bis(4-fluorophenyl)-3-(1 -methyl- 1H-tetrazol-5-yl)-1 (E), 3-[2- uC]butadienyl-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one... 

Example 20 diallyl-iV,N-diisopropylphosphoroamidite has been prepared by Bannwarth and Kiing and employed in the phosphitylation of the peptide hydroxy function [49]. The phosphitylation by this reagent proceeds in the presence of tetrazole (step a) followed by CBPA oxidation (step b) and removal of allyl protecting groups in the presence of Pd(0)P(C6H6)3 (step c). 

The thionucleoside with a free 5 -hydroxy group was phosphitylated in the presence of tetrazole or TMCS (step a) and the intermediate formed coupled with 5 -0-acetylthymidine activated by DBU (step b). The addition of elemental selenium (step c) is followed by the fast demethylation in the presence of 4-nitrophenoxide (step d). All these operations can be performed as a one-flask procedure to give the desired product in over 90% yield. 

Tetrazol-5-ones (A nhydro-S-hydroxy-1,2,3,4-tetrazolium Hydroxides) (289)... 

Acylamino-benzoesaure-azide, in situ durch Substitution mit Azid hergestellt, spalten ther-misch Stickstoff ab und lagem sich nach einem identischen Reaktionsweg (s. o.) zu 2-Hydroxy-benzimidazolen um. Als Konkurrenzreaktion kann das Azid zum Tetrazol cyclisieren607. 

Hydroxy-tetrazole. See Tetrazolol and Derivatives. These, include ... 

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