Tetraisopropyl methylenediphosphonate

Acetyl hypofluorite (CH3CO2F) > has been used to fluorinate tetraisopropyl methylenediphosphonate in two steps. In the first step, the sodium salt of tetraisopropyl methylenediphosphonate is added to a solution of AcOF in CFCI3 at -78°C. After 5 min, the reaction is quenched, and tetraisopropyl fluoromethylenediphosphonate is isolated in 66% yield. This compound is metallated with NaH and submitted to a second electrophilic fluorination as above to obtain tetraisopropyl difluoromethylenediphosphonate in 40% yield. Even if acetyl hypofluorite seems to be a more selective reagent for electrophilic monofluorination than FCIO3, its relative instability and the special equipment required to manipulate moleculai fluorine greatly limit its use. 

Manuf./Distrib. DuPont http //www.dupont.com Tetraisopropyl methylenediphosphonate CAS 1660-95-3 Empihcal Ci3H oOeP2... 

TiPMDP. See Tetraisopropyl methylenediphosphonate TiPP. See Triisopropyl phosphite TIPS-chloride TIPSCI. See 1,3-Dichlorotetraisopropyldisiloxane TIPS triflate. See Triisopropylsilyl trifluoromethane sulfonate TIPT. See Tetraisopropyl titanate Ti-Pure R-100, Ti-Pure R-101 Ti-Pure R-102 Ti-Pure R-103 Ti-Pure R-104 Ti-Pure R-794 Ti-Pure R-795 Ti-Pure R-900, Ti-Pure R-902 Ti-Pure R-960 Ti-Pure RPD Vantage , Ti-Pure RPS Vantage . See Titanium dioxide Tirpilene. See a-Terpinene TISC. See Triisostearyl citrate... 

Tetraisopropyl methylenediphosphonate intermediate, propoxylated surfactant Tetrahydroxypropyl ethylenediamine intermediate, propylene oxide Propylene Propylene glycol acetate intermediate, proton pump inhibitor synthesis 3-Methoxy-1-propanoi intermediate, PS piasticizers Methyi oieate... 

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