1,3,6,8-tetrahydroxynaphthalene reductase

Several fungicides inhibit 1,3,6,8-tetrahydroxynaphthalene reductase (MBI-Rs) (Table 20.2). These inhibitors have been used since the 1970s, such as pentachlor-obenzyl alcohol (PCBA) (6), tricyclazole (7) (Eli Lilly, 1975), pyroquilon (8) (Ciba, Pflzer, 1985) and fthalide (9) (Kureha, 1971), without any resistance problems and retain considerable economical importance, mainly in Northeast Asia. They are not discussed in more detail here. 

Table 20.2 Structures of inhibitors of 1,3,6,8-tetrahydroxynaphthalene reductase in DHN melanin biosynthesis.

Schatzle, M.A., Flemming, S., Husain, S. M., Richter, M., Gunther, S., and Muller, M. (2012) Tetrahydroxynaphthalene reductase catalytic properties of an enzyme involved in reductive asymmetric... 

---