Tetrahydroxy chalcone

The main flavonoid skeleton derives from the stepwise condensation of three molecules of malonyl CoA with one molecule of 4-coumaroyl CoA, a reaction catalyzed by chalcone synthase (CHS) to form naringenin (2, 4,4 ,6,-tetrahydroxy) chalcone, the common intermediate in the formation of all flavonoids with 5,7-dihydroxy (flavone numbering) A-ring substitution. In some plants, however, an NADP-dependent chalcone-ketide reductase coacts with CHS to form 6 -deoxychalcone, the precursor of 5-deoxyflavonoids. The resulting chalcones undergoe a stereospecific cyclization to the corresponding (2S) flavanones, the... 

Tetrahydroxy-chalcone) [wood] glycosides in Coreopsis, activation ( DNA... 

H OH H p-Coumaryl CoA 2, 4,4, 6 Tetrahydroxy- chalcone Naringenin Dihydro- Apigenin kaempferol (Aromadendrin)... 

Type III PKSs are small, homodimeric enzymes which can be found in both plants and a wide array of microbes. They generally construct fairly low molecular weight 1-2 ring aromatic molecules.36 Examples include plant chalcone and stilbene synthases and the S. coelicolor gene tetrahydroxy naphthalene synthase (THNS), each of which has been structurally characterised by X-ray diffraction. These enzymes are often easy to express het-erologously in E. coli and much work has been done to understand their complicated enzymology as a model for the larger, more complex Type I and II systems.2... 

Hesperidin chalcone (= Chalcone 2, 4, 6, 3-tetrahydroxy-4-methoxy 4 -0-Rut) (chalcone 0-glycoside)... 

CisHjjOe M 288.256 3 -Me ether [6542-59-2]. l-(2,4-Dihydroxy-3-methoxyphenyl)-3 (3,4 dihydroxyphenyl)-2-propen-l-one. 2, 3,4,4 - Tetrahydroxy-3 -methoxychalcone. Lanceoletin Ci HiA M 302.283 Rare chalcone present in floral tissues of some Compositae. 

---