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Tetrahydrohomofolic Acid

Another potent candidate is 5,10-dideaza-5,6,7,8-tetrahydrohomofolic acid (HDDATHF) <90JOC3222> whose mechanism of action again involves inhibition of GAR-Tfase in de novo purine biosynthesis. [Pg.729]

Potential Antimetabolites — Several new types are reported to be active against drug-resistant malarial parasites in experimental animals. Tetra-hydrohomopterolc acid (Va) was effective against both normal and pyrimethamine-resistant P. cynomolgi in monkeys, but tetrahydrohomofolic acid (Vb)... [Pg.133]

Inhibition of thymidylate synthetase by tetrahydrohomofolic acid does not appear to be responsible for its activity against methotrexate-resistant mouse leukemias it may be acting by preventing the uptake of... [Pg.156]

Folic Acid Antagonists - In certain cells folic acid antagonists, such as methotrexate (MTK), homofolic acid or tetrahydrohomofolic acid, inhibit the Incorporation of the C-8 carbon into 4-aminoimidazole-5-car-boxamide rlbotlde. Inhibition of DNA synthesis by MIX and related antagonists is not selective, but is balanced by concurrent inhibition of RNA and/or protein synthesis.37 39 therapeutic advantage with reduced toxi-... [Pg.131]

See other pages where Tetrahydrohomofolic Acid is mentioned: [Pg.727]    [Pg.51]    [Pg.727]    [Pg.51]    [Pg.54]    [Pg.275]   
See also in sourсe #XX -- [ Pg.156 ]



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