Tetracycline INDEX

Fig. 2 Distribution of the sorted version of the P values for all reactions of the parasite for the tetracycline treatment (a) and the chloroquine treatment (b) compared with control. Each gene indexed is plotted on the /-axis and its corresponding Wilcoxon Pvalue is plotted on the y-axis...

Before the introduction of specific vasopressin receptor antagonists, pharmacological treatments for hyponatremia centered on the use of loop diuretics and nonspecific inhibitors of vasopressin signaling, such as lithium carbonate and demeclocycline.11 The utility of such therapies has been limited by a range of sideeffects. Loop diuretic use can result in electrolyte imbalances and suffers from poor response predictability.11 Lithium carbonate suffers from a low therapeutic index and a risk of renal damage as well as limited effectiveness in many patients. Lithium carbonate has therefore been nearly completely supplanted by demeclocycline, a tetracycline antibiotic, in the treatment of chronic hyponatremia.12 Demeclocycline use is itself limited by its nephrotoxicity (particularly in cirrhotic patients), ability to cause reversible uremia, and ability to induce photosensitivity.1,11... 

Women comprise 51% of the population of most nations in Western countries, 54% of women are of child-bearing potential (15 9 years). Women account for 57% of physician visits (National Disease and Therapeutic Index ) (FDA, 1986). In the age group 20-39 years, women were found to be the biggest users of anti-infectives, especially ampicillin and amoxicillin antidepressants are prescribed twice as often to women as to men (Stewart, 1998) and of some concern was that tetracycline, a known teratogen, was the eighth most prescribed drug in this group most likely to bear children (FDA, 1986). 

Figure 2 illustrates the basic content of a Registry substance record. The substance is tetracycline. Included are the CAS Registry Number, the CA Index Name, some synonymous chemical names, the molecular formula, and a stereospecihc structural diagram. An integral part of the CAS Chemical Registry System is the Registry Nomenclature File which contains the CA Index Name, and other systematic, semisystematic, and common names encountered in the chemical literature. 

---