2,3,7 8-Tetrachlorodi benzo-p-dioxin

Owing to the fact that ethyl ethers are especially effective substrates for CYP1A1 [184], the probe possesses an ethyl group on the phenolic oxygen of the trimethyl lock. In vitro, fluorescence was manifested by CYP1A1 isozyme with Kcat/KM 8.8 x 103 M-1s 1 and KM 0.09 pM. In cellulo, the probe revealed the induction of cytochrome P450 activity by the carcinogen 2,3,7,8-tetrachlorodi-benzo-p-dioxin (TCDD), and its repression by the chemoprotectant resveratrol. 

Okey, A.B., Bondy, G.P., Mason, M.E., Nebert. D.W., Forstergibson, C., MuncaN, j., and Dufresne, M.J. (1980). Tfemperature-dependent cytosol-to-nuclease translocation of the Ah receptor for 2,3,7,8-tetrachlorodi-benzo-p-dioxin in continuous cell culture lines, J. BioL Chem. 255,11415. 

LEUNG, H.W., WENDLING, J.M., ORTH, R., HILEMAN, F. and PAUSTENBACH, D.J. (1990). Relative distribution of 2,3,7,8-tetrachlorodi-benzo-p-dioxin in human hepatic and adipose tissues, Toxicol. Lett. 50, 275-282. 

Johnson J (1995), Environ. Sci. Technol. 29 24A-25A. Dioxin risk Are we sure yet Neidhard H (1990), Vortrag auf dem GDCh Info-Tag 496/90. Das internationale System der toxischen Aquivalente und Bewertung von Quellen", Frankfurt, 09.03.1990 U.S. EPA (1994), EPA 600/BP-92/001C. Health Assessment Document for 2,3,7,8-Tetrachlorodi-benzo-p-dioxin (TCDD) and Related Compound, Vol. Ill External Review Draft", U.S. EPA, Office of Health and Environmental Assessment, Washington, D.C. 

Wiebel FJ, Wegenke M, Kiefer F. Bioassay for determining 2,3,7,8-tetrachlorodi-benzo-p-dioxin equivalents (TEs) in human hepatoma HepG2 cells. Toxicol Lett 1996 88 335-8. 

Jirasek L, et al Chronic poisoning by 2,3,7,8-tetrachlorodi-benzo-p-dioxin. Cesk Dermatol 49 145-157, 1974,... 

Canga, L., R. Levi, and A. B. Rifkind. 1988. Heart as a target organ in 2,3,7,8-tetrachlorodi-benzo-p-dioxin toxicity decreased /1-adrenergic responsiveness and evidence of increased intracellular calcium. Proc. Natl. Acad. Sci. USA 85(3) 905-9. 

Chloroanisoles, chloro-methylanisoles 2,3,7,8 tetrachlorodi-benzo-p-dioxin... 

SYNS 2,3,7,8-czTEROCHLORODVc UBENZo-p-DWUOKSYNY (POLISH) DIOKSYNY (POLISH) DIOXIN (herbicide contaminant) DIOXINE NCI-C03714 TCDBD 2,3,7,8-TCDD 2,3,6,7-TETRACHLORODI-BENZO-p-DIOXIN 2,3,7,8-TETRACHLORODlBENZO-(b,e)(l,4)DIOXAN 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN 2,3,7,8-TETRACHLORODIBENZO-l,4-DIOXIN TETRADIOXIN... 

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