Tests for Safety of Intravenous Anesthetics

Besides determination of the ratio between anesthetic and lethal dose, intravenous anesthetics have to be tested for their influence on the cardiovascular and 

Cardiopulmonary parameters and rectal body temperature are determined while the rabbit is in the sling and also at 15 min intervals following induction of anesthesia with the rabbit in lateral recumbency. Heart rate, mean arterial blood pressure, respiratory rate and respiratory pattern are calculated from tracings from the physiological recorder. Arterial blood pH, partial pressure of oxygen (PaQz), and partial pressure of 

Details of anesthesia in the rabbit were also described by Murdock (1969). 

Peeters et al. (1988) performed a comparative study of four methods for general anesthesia in rabbits. 

Glenn (1980) examined the anesthetic activity of propofol (ICI 35868) in mice, rats, rabbits, cats, pigs and monkeys, including cardiovascular and respiratory parameters and EEG studies. 

---