4- tert.-Butyl-1 -nitro

Bis- 3-(bzw.4)-[2,2-dimethyl-2-(2-hydroxy-propyl)-1 -dehydro-hydrazinocarbonyl]-phenyl - 687 Bis-[2-methy]-phenyl]- 538 -bis-phosphonsaure-diester 523 Bis-[trifluormethy]]- 538 tert.-Butyl-( 1-hydroperoxy-cyclopentyl)- 571 tert.-Butyl-( 1 -hydroxy-cyclopentyl)- 571 (4-Chlor-phenyl)-(2-nitro-phenyl)- 693 (4-Chlor-phenylthio)-(4-nitro-phenyl)- 700 [Cyclohexen-(l)-yl]-phenyl- 368 Diaryl- 550, 552, 558, 567 Diphenyl-... 

Dimethyl-benzyl- 648, 678 Dimethyl-tert.-butyl- 649, 661 Dimethyl-cyanmethyl- 648, 678 Dimethyl-(4-nitro-benzyl)- 678 Trimethyl- 648... 

Chlor-l-athoxycarbonylamino- 675 1 -Chlor-1 -butyl- 586 4-Chlor-4-methyl-l -tert.-butyl- 511 1-Chlor-l-nitro- 575 1-Chlor-1 -nitroso- 472 l-Chlor-2-oxo-l-athoxycarbonyl- 674 1-Cyanamino-1,2-dimethyl-105 Cyan- 109, 587 1 -Deutero-l-methyl-... 

Brom-l-(2-chlor-athyl)- 623 4-Brom-l-(l-hydroxy-athyl)- 308, 607 4-Brom-l -jod- 624 Brommethyl- 505 4-Brom-l-methyl- 172 4-Brommethyl-l-tert.-butyl- 625 Brom-nitro- 621... 

Recently, the oxidation of primary aliphatic amines to the corresponding nitro compounds has also been achieved using the catalyst system based on zirconium tetra tert-butoxide and tert-butyl hydroperoxide in a molecular sieve (50-98% yield) (Eqs. 2.56 and 2.57 and Table... 

Enantioselective allylations of a-nitro ketones and a-nitro esters with allyl acetates are carried out in the presence of 2 equiv of alkali metal fluorides (KF, RbF, CsF) and 1 mol% palladium catalysts prepared in situ from Pd2(dba)3-CHC13 and chiral phosphine ligands. Moderate enantio-selectivity (ca 50% ee) is reported for allylation of cx-nitroketones (Eq. 5.60). The highest selectivity (80% ee) is observed for allylation of the reaction of tert-butyl ester (Eq. 5.61).93... 

MK-447, 2-aminomethyl-4-tert-butyl-6-iodophenol MNNG, 1 -methyl-3-nitro-1 -nitrosoguanidine MPO, myeloperoxide... 

Steric effects are also apparent in the activities of several mutagens in series 28. In Fig. 29 the 4-tert-butyl group in 281, the 4-nitro substituent in 28h and perhaps the CHO in 28f result in lower activity than would be expected on electronic grounds alone. 

However, this multistep procedure is experimentally complex. A simpler variation described in 199127 consists of the reaction of an aldehyde and a nitro compound in the presence of triethylamine, TBAF and tert-butyl-dimethylsilyl chloride. Under these conditions, nitro sugars are obtained in good yieds and higher diastereoselectivities than those afforded by the standard conditions. This procedure was used in several synthesis of 2-nitro-2-deoxyaldoses, as for the condensation of l,l-diethoxy-2-nitroethane and l,2 3,4-di-0-isopropylidene-a-D-galacto-hexodialdo-l,5-piranose.28 More recently, it was applied to the addition of ethyl nitroacetate to the D-glucose derived aldehyde 18, to give nitro sugar derivatives 26, key precursors of polysubstituted cyclohexane a-amino acids (Scheme 10).29... 

Scheme 6.2 represents Sj j l substitution that takes place when sodium thiophenolate attacks e,4-tert-butyl-c,2-methyl-fl,4-nitro-e,4-(4-nitrophenyl) cyclohexane. Light irradiation stimulates the reaction. It is carried out under nitrogen in HMPA. The ion-radical type of the process has been established by means of inhibitors. It was found that the stereochemical outcome of the reaction depends on the concentration of the PhSNa nucleophile. At a low concentration of PhSNa, the reaction leads to a mixture of phenylthiyl derivatives the content of a,SPh-substituted product is higher than that of c,SPh product by 20%. At a high concentration of PhSNa, the reaction produces practically a single stereoisomer bearing the a-PhS group. 

Die Hydrolyse von 3-tert.-Butyl-2-nitro-l-pyrrolidino-l,3-cycloheptadien mit 20%iger Schwefelsaure liefert 2-tert.-Butyl-3-nitro-4-oxo-cyclohepten (76%) ... 

Bei der Nitrierung von Benzol, Toluol, Ethyl-benzol, tert.-Butyl-benzol und Chlorbenzol mit Titan(IV)-nitrat in Tetrachlormethan entstehen die entsprechenden 2-Nitro- bzw. 4-Ni-tro-Derivate in ausgezeichneter Ausbeute4,5 ... 

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