Terminal weaning

V. Patient Request for Treatment Withdrawal or Terminal Wean... 

Further studies showed that during the pubescent period, CLA reduced the development and branching of the expanding mammary ductal tree. There was also a reduction in the density and rate of proliferation of terminal end bud (TEB) cells. TEBs are the least differentiated and most actively growing glandular ductal structures, which are most abundant from weaning to puberty and are the site of chemically induced tumors (Ip et al., 2003). 

Intestinal transplantation is combined with liver transplantation in 46% of cases, because of terminal liver failure (93). Of 78 patients who had received parenteral nutrition for more than 2 years n — 66) and/ or had short bowel syndrome and could not be weaned from parenteral nutrition (n = 12), 58 developed chronic cholestasis and 37 developed one or more severe liver complication (serum bilirubin concentration 60 pmol/l, factor V (proaccelerin) 50%, portal hypertension, encephalopathy, ascites, bleeding from the gastrointestinal tract, or histological findings consisting of extensive fibrosis and cirrhosis) after 6 (3-132) months and 17 (2-155) months respectively. Liver disease was responsible for deaths in 6.5% of the patients (22% of deaths). 

Curtis JR. Terminal care for the ventilator dependent patient. Abstracts of Papers, International Consensus Conference in Intensive Care Medicine Weaning from Mechanical Ventilation, Budapest, Hungary, April 28-29, 2005. Convened by five major scientific societies. 

Figure 1. Effect of merino, maternal and terminal sires estimates for (a) post weaning weight...

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