Terfenadine Calcium-channel blockers

Benzodiazepines alprazolam, clonazepam, diazepam, midazolam, triazolam, zolpidem Calcium channel blockers diltiazem, nifedipine, nimodipine, verapamil Steroids androgens, estrogens, cortisol Others erythromycin, terfenadine, cyclosporine, dapsone, ketoconazole, lovastatin, lidocaine, alfentanil, amiodarone, astemizole, codeine, sildenafil... 

CYP3A4 alprazolam, calcium channel blockers, cisapride, clarithromycin, cyclosporin A, erythromycin, HIV protease inhibitors, lidocaine, midazolam, simvastatin, terfenadine carbamazepine, dexamethsone, phenobarbital, phenytoin, rifampicin, St John s wort cimetidine, erythromycin, grapefruit juice, HIV protease inhibitors, itraconazole, ketoconazole... 

Differences in metabolism among patients can lead to differences in susceptibility to ADRs e.g. patients with abnormal pseudocholinesterase levels have prolonged apnea after receiving succi-nylcholine patients with low activity of A-acetyl transferase are more likely to develop lupus-like reactions to procainamide, hydralazine, and isonia-zid and variants of the cytochrome P-450 family of enzymes can lead to altered metabolism of a variety of drugs, including antidepressants, antiarrhythmic agents, codeine, metoprolol terfenadine, cyclosporine, calcium channel blockers, and others (Peck et al 1993). 

Adverse reactions to somatostatin analogues have been extensively reported. The asymptomatic effects have been reviewed [23, 34 ]. There are asymptomatic gallstones in 20-40, bradycardia in up to 25%, and conduction abnormalities in 10%. Somatostatin analogues may alter the absorption of other drugs, especially oral hypoglycemic agents, p blockers, calcium channel blockers, and dclosporin, while effects on CYP isoenzymes may alter concentrations of quinidine, terfenadine, and warfarin. Somatostatin analogues... 

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