Terbinafine Cimetidine

Haloperidol Fluoxetine214 Methadone Mibefradil Paroxetine214 Quinidine3 " Sertraline Terbinafine Cimetidine Qarithro- mycin" 4 Gestodene Nelfinavir"4 Verapamil ... 

Drugs that may interact with terbinafine include the following Cimetidine, rifampin, terfenadine, caffeine, dextromethorphan, cyclosporine. 

TERBINAFINE H2 RECEPTOR BLOCKERS -CIMETIDINE t efficacy and adverse effects of terbinafine t bioavailability Consider alternative acid suppression or monitor more closely and consider 1 dose... 

A 71-year-old woman taking a stable dose of warfarin and cimetidine was treated with terbinafine, and 32 days later developed profuse intestinal bleeding associated with a prothrombin time of 120 seconds, suggestive of an interaction between warfarin and terbinafine, either directly or through the mediation of cimetidine (which can reduce terbinafine clearance by 33%) (74). 

Cimetidine modestly increases the AUC of terbinafine. However, no clinically relevant interactions appear to have been reported between terbinafine and cimetidine or ranitidine. 

In a study in 12 healthy subjects cimetidine 400 mg twice daily for 5 days increased the AUC of a single 250-mg dose of terbinafine by 34% and reduced its clearance by 30%4 The likely reason is that cimetidine (a known enzyme inhibitor) reduces the metabolism ofterbinafme by the liver. However, it seems that this modest increase in the serum levels of ter-binafme is of little or no clinical relevance, because in a large scale postmarketing survey of patients taking terbinafine no interactions were reported in patients also taking cimetidine or ranitidine [number un-... 

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