Tensor-based morphometry

Lu et al. [101] used Tensor-based morphometry (TBM), a novel computational approach for visualizing longitudinal progression of brain atrophy, to determine whether cognitively intact elderly participants with the e4 allele demonstrate greater volume reduction than those with the e2 allele, and found that possession of the e4 allele is associated with greater temporal and hippocampal volume reduction well before the onset of cognitive deficits. 

Lu PH, Thompson PM, Leow A, Lee GJ, Lee A, Yanovsky I et al (2011) Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults A tensor-based morphometry study. J Alzheimers Dis 23 433-442... 

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